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NEW OPPORTUNITIES IN DRUG TREATMENT OF ATOPIC DERMATITIS - PDF (Russian)
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One of the main causes for adverse reactions development is not taking into account the pharmacokinetics of drugs and the dose. Pharmacokinetics of drugs is mostly defined by the cytochrome P isoenzymes activity, carboxylesterases and many other isoenzymes of drug metabolism, as well as ADME transporters P-gp etc. The activity of these isoenzymes is defined by the genetic aspects of patients and non-genetic aspects such as comorbidity and drug-drug interactions. The development of complex algorithms for personalization of therapy based on the results of pharmacogenetic studies and in the form of a decision support system will play an important role in reduction of adverse drug reactions.
